Pharmaceuticals impurities are the unwanted chemicals that remain or are generated during the formulation of medicines. Impurity profiling helps in detection, identification and quantification of various types of impurities as well as residual solvents in bulk drugs and in pharmaceutical formulations. It is a best way to characterize quality and stability of bulk drugs and pharmaceutical formulations. Due to rapid development of the analytical methodology it is imperative to review problems related to impurities present in the drug substances and drug products. Identification of impurities is done by variety of Chromatographic and Spectroscopic techniques, either alone or in combination with other techniques. There are different methods for detecting and characterizing impurities with TLC, HPLC, HPTLC, AAS etc. Conventional Liquid Chromatography, particularly, HPLC has been exploited widely in field of impurity profiling; the wide range of detectors, and stationary phases along with its sensitivity and cost effective separation. Thus enlightening the need of impurity profiling of drug substances in pharmaceutical research this review focuses on various analytical methods for identification as well as quantification of impurities present in the pharmaceuticals.
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